复旦研究生《细胞免疫》T细胞免疫应答及其效应.pptVIP

;;Overview of generation of T cell and T cell responses in vivo ;;Types of adaptive immune responses;. ;Types of cell-mediated immune reactions; CD4+ Th1 responses microbes residing within the phagosomes of phagocytes CD8+ CTL responses microbes residing in the cytoplasm of various cell types CD4+ Th2 responses helminthic parasites CD4+ Th17 responses extracellular bacteria, fungi…..;Major mediators of T cell-mediated immune responses;Th1-Mediated Immune Responses;Effector functions of Th1 cells;;T cell signals that activate macrophages ;IFN-?;CD40L/CD40;The effector functions of activated macrophages ;Activation and functions of macrophages in CMI;Th2-Mediated Immune Responses ;Effector functions of Th2 cells;Effector functions of Th2 cells;The effector function of Th2 cytokines;The orchestration of macrophage activation and polarization by Th cells; The physiological role of Th17 cells Protection against extracellular bacterial and fungal infections Pathological roles of Th17 cell may be important in meditating tissue damage in immune-mediated inflammatory diseases, e.g. autoimmune diseases ;Th17-specific cytokines;Effects of Interleukin-17 on Cell Functions and Its Role in the Pathophysiology of Diseases.;IL-22;OConnor Jr et al. Nature Immunol 2010; Bettelli E, T Korn, M Oukka, and VK Kuchroo. Induction and effector functions of TH17 cells. Nature 453:1051-1057, 2008 Dong C. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nature Reviews Immunology 8:337-348, 2008. Farrar JD, H Asnagli, and KM Murphy. T helper subset development: roles of instruction, selection, and transcription. Journal of Clinical Investigation 109:431-435, 2002. Korn T, E Bettelli, M Oukka, and UK Kuchroo. IL-17 and Th17 cells. Annual Review of Immunology 27, 2009 McGeachy MJ, and DJ Cua. Th17 cell differentiation: the long and winding road. Immunity 28:445-453, 2008. Ouyang W, JK Koll