复旦研究生《细胞免疫》抗原递呈细胞和抗原递呈.pptxVIP

抗原递呈细胞和抗原递呈;Kill;T Cell Functions;Cytotoxic T cell (CTL, CD8+)Directly kill virus-infected cell;Helper T cells (Th, CD4+)Activate Macrophages and B cells;抗原递呈;Challenges for T cells to overcome;Challenges for T cells to overcome;;抗原递呈;How do T cells recognize Ag?;The T-cell receptor resembles a membrane-associated Fab fragment of immunoglobulin;;Every TCR is specific for a combination of a peptide Ag and parts of MHC (MHC restriction).;MHC I and MHC II;MHCI, all nucleated cells MHCII, APC;MHC cell surface expression;Peptide-MHC I? CD8 T cell;Antigen-presenting Cells (APC);APCs:Specialized cells that present Ags to CD4+ T cells ;Activate na?ve or effector T cells. Present Ag to T cells and provide the 2nd signal. Microbial products enhance the antigen-presenting function of APCs. Bidirectional interaction between APC and T cells.;Activate na?ve or effector CD4+T cells. Express MHC II DC ? na?ve T cells Mac, B ? activated T;Activate na?ve or effector T cells. Present Ag to T cells and provide the 2nd signal. Microbial products enhance the antigen-presenting function of APCs. Bidirectional interaction between APC and T cells.;Na?ve T cell activation requires 2 signals;Na?ve T cell activation requires 2 signals;Immune Synapse;Activate na?ve or effector T cells. Present Ag to T cells and provide the 2nd signal. Microbial products enhance the antigen-presenting function of APCs. Bidirectional interaction between APC and T cells.;Innate Recognition (PAMP and PRR);;PAMP Enhances Antigen-presenting functions of APCs;Adjuvant (microbial products or derivatives)Immunologist’s dirty little secret;Activate na?ve or effector T cells. Present Ag to T cells and provide the 2nd signal. Microbial products enhance the antigen-presenting function of APCs. Bidirectional interaction between APC and T cells.;;Dendritic Cells;Ralph.M.Steinman, Rockfeller University Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. 1973, J Exp Med. ;T