免疫球蛋白的结构-功能的联系.pptVIP

Immunoglobulin Structure-Function Relationship;Signalling antigen receptors on B cells - bifunctional antigen-binding secreted molecules（B 细胞表面受体和分泌的抗体） Structural conservation and infinite variability - domain structure（结构上不仅保守而且无限可变的）. The Immunoglobulin Gene Superfamily （免疫球蛋白的超家族） The immunoglobulin fold （免疫球蛋白的折叠） Framework and complementarity determining regions - hypervariable loops （框架结构和可变区） Modes of interactions with antigens （与抗原相互作用的模型） Effector mechanisms and isotype – role of the Fc. （Fc 区的作用） Multimeric antibodies and multimerisation Characteristics and properties of each Ig isotype Ig receptors and their functions;Cell surface antigen receptor on B cells B 细胞表面受体和分泌的抗体 Allows B cells to sense their antigenic environment Connects extracellular space with intracellular signalling machinery Secreted antibody （抗体） Neutralisation （中和作用） Arming/recruiting effector cells （激活或者诱导功能细胞） Complement fixation （帮助机体对抗原的清除） ;Immunoglobulins are Bifunctional Proteins;Structural conservation and a capacity for infinite variability in a single molecule is provided by a DOMAIN structure. （结构上不仅保守而且无限可变的- 抗体结构域） Ig domains are derived from a single ancestral gene that has duplicated, diversified and been modified to endow an assortment of functional qualities on a common basic structure（Ig结构域源于一个原始基因，复制，多元化，修饰等） Ig domains are not restricted to immunoglobulins （Ig 结构域不仅仅局限于免疫球蛋白）. The most striking characteristic of the Ig domain is a disulphide bond - linked structure of 110 amino acids long（Ig结构域最明显的特点是其双硫键，连接了110个氨基酸）.;The genes encoding Ig domains are not restricted to Ig genes. Although first discovered in immunoglobulins, they are found in a superfamily of related genes, particularly those encoding proteins crucial to cell-cell interactions and molecular recognition systems. IgSF molecules are found in most cell types and are present across taxonomic boundaries;Antibodies are Proteins that Recognize Specific Antigens 抗体能够特异性的识别抗原;Epitopes（抗原决定簇