注射用头孢唑肟钠与4种药物的配伍稳定性考察.PDF

注射用头孢唑肟钠与4种药物的配伍稳定性考察 盛高峰 1＊，刘 佳 2[1.南通大学第二附属医院，江苏 南通 226001；2.永信药品工业（昆山）有限公司，江苏 昆山 215331] 中图分类号 R969.1；R978.1 文献标志码 A 文章编号 1001-0408（2015）14-1944-04 DOI 10.6039/j.issn.1001-0408.2015.14.23 摘 要 目的：考察注射用头孢唑肟钠与 4 种常用药物配伍的稳定性。方法：采用高效液相色谱法测定注射用头孢唑肟钠与氨茶 碱注射液、维生素C注射液、地塞米松磷酸钠注射液、酚磺乙胺注射液在5％葡萄糖注射液中配伍后的含量变化，并考察外观及pH 值变化。结果：注射用头孢唑肟钠与上述4种药物配伍6 h内溶液外观以及4.5 h内pH 值和含量均无明显变化。结论：注射用头孢 唑肟钠与维生素 C 注射液、氨茶碱注射液配伍后随着时间的变化，头孢唑肟钠的含量有逐渐减少的趋势，在实际应用中宜在配伍 后4 h内滴注完毕。 关键词 头孢唑肟钠；维生素C注射液；地塞米松磷酸钠注射液；氨茶碱注射液；酚磺乙胺注射液；高效液相色谱法；配伍；稳定性 Study on the Stability of Ceftizoxime Sodium for Injection Combined with 4 Kinds of Drugs SHENG Gao-feng1，LIU Jia2[1.The Second Affiliated Hospital of Nantong University，Jiangsu Nantong 226001， China；2.Yungshin Pharm. Ind.（Kunshan）Co.，Ltd.，Jiangsu Kunshan 215331，China] ABSTRACT OBJECTIVE：To study the stability of Ceftizoxime sodium for injection combined with 4 common drugs. METH- ODS：HPLC was conducted to determine the changes of contents after Ceftizoxime sodium for injection combined with Aminophyl- line injection，Vitamin C injection，Dexamethasone sodium phosphate injection and Etamsylate injection in 5％ Glucose injection. The changes of appearance and pH were detected. RESULTS：There were no obvious changes among the appearance (within 6 h)， pH（within 4.5 h）and content（within 4.5 h）when Ceftizoxime sodium for injection combined with above-mentioned drugs. CON- CLUSIONS：The content of Ceftizoxime sodium is gradually decreased with the changes of combination with Vitamin C injection and Aminophylline injection. Infusion should be finished within 4 h in clinic. KEYWORDS Ceftizoxime sodium；Vitamin C injection；Dexamethasone sodium phosphate；Aminophylline injection；Etamsyl- ate；HPLC；Compatibility；Stability 头孢唑肟钠属第三代头孢菌素，具广谱抗菌作用，对多种