-aminobutyric acid A receptor in rats with acute cerebral ischemia changes.docVIP

 PAGE \* MERGEFORMAT 15 -aminobutyric acid A receptor in rats with acute cerebral ischemia changes On: Sun Zhimin Mao-Lin Zhang Jun-Qing Zhang Xue Ji-jiao [Abstract] Objective: To observe the cerebral cortex of -aminobutyric acid A receptor (-aminobutyric acid A receptors, GABAAR) in different periods of ischemia and dynamic changes of expression of the law of acute cerebral ischemia in the change in meaning. Methods: 65 male Wistar rats were randomly divided into control group, cerebral ischemia 6 h group, 12 h group, 24 h group, 3 d group, 7 d group, 14 d group (surgery group were ), sham group; with middle cerebral artery occlusion (MCAO) model to the specified point in time to take brain tissue, HE staining, neurons were observed with an optical microscope injury; used immunohistochemistry to determine the expression of neuron-positive strength; using morphological analysis system to detect the expression of positive cells GABAAR. Results: The expression of each operation group GABAAR than the sham group and control group, compared with the control group, ischemia and 6 h decreased the expression of both, to 12 h to a minimum. the sham group and control group had no statistical significance. Conclusion: Acute cerebral ischemia can cause GABAAR downregulated, resulting in its inhibition of excitatory amino acid reduced toxicity, such rates and reduced the extent and severity of cerebral ischemia is consistent, suggesting GABAAR in ischemic brain injury in a neuroprotective effect, may slow down the process of ischemic cerebrovascular disease, while the main GABAAR as a brain nerve delivery of inhibitory amino acids quality receptors, in addition, through its ligand-gated Cl-channels mediate the effects of confrontation “excitotoxic” effect outside, GABAAR itself due to ischemia caused by changes in physical and chemical factors change. [Keywords:] Cerebral ischemia; -aminobutyric acid A receptor; rat Abstract Objecive: To observe the expression o