1 h of warm ischemia in isolated porcine pulmonary artery smooth muscle function.docVIP

 PAGE \* MERGEFORMAT 13 1 h of warm ischemia in isolated porcine pulmonary artery smooth muscle function OF: He Zhanfeng Zhao Song Wang Zuopei Li Xiaohui Zhang Feng Ding Kai Wei Haitao Gong Shi Ning [Abstract] Objective 1 h of warm ischemia on the “no heart-beating donor,” the impact of pulmonary artery smooth muscle function, as “no heart-beating donor” lung scientific basis for clinical application. Methods 16 Swedish domestic pigs were randomly divided into a heartbeat donor (heart beating donor, HBD group and the non-heart-beating donor (non heart beating donor, NHBD group, respectively, about 1.5 mm diameter for the pulmonary artery segment, 1.5 mm long as no branch of the pulmonary artery, with the device and Tissue Organ Bath high potassium Krebs solution, thromboxane A2 (TXA2 analogue U 46619 and the determination of papaverine in vascular smooth muscle contraction and relaxation function. Results NHBD group compared with the HBD group, high-K Krebs solution induced by the shrinkage (mN) difference (25.81 + -1.86,26.80 + -1.59 was not significant (Pgt; 0.05, U 46619-induced contraction value (mN) difference (18.63 + -2.24,20.23 + -2.09 was not significant (Pgt; 0.05, and can fully diastole. conclusions of NHBD warm ischemia 1 h preserved pulmonary artery smooth muscle contraction and relaxation. [Keywords:] pigs, pulmonary artery, no heart-beating donor lung transplantation, U 46619 Toronto Lung Transplant Group in 1983 first reported the successful long-term survival of lung transplant experience (1). Followed by many countries, an increasing number of lung transplantation (2). However, due to the severe lack of donors, more and more patients the process of waiting for the dead body (3). In this study, Tissue Organ Bath Apparatus and are more heart-beating donor (heart beating donor, HBD) and non-heart-beating donor (non heart beating donor, NHBD) systolic and diastolic pulmonary artery function of the lung warm ischemia for 1 h the feasibi