5 diesel particles in the serum of mice Deoxyschizandrin Pharmacokinetic Studies.docVIP

 PAGE \* MERGEFORMAT 10 5 diesel particles in the serum of mice Deoxyschizandrin Pharmacokinetic Studies Author: Guoqing Ying Wang Zhenhua Zhang Chang-shui Chen Yang Zhao-Qiang Zhang [Abstract] Objective To study the five diesel particles in drug metabolism in mice Schisandra law. Methods Mice were fed for five diesel particle 2 g / kg, at different time points blood samples, using high performance liquid chromatography (HPLC) to analyze five diesel particles and serum samples deoxyschizandrin composition, measured Deoxyschizandrin The change of concentration, rendering the concentration - time curve. The results showed that diesel particles in the main components of Schisandra Deoxyschizandrin, the average content of 3.13 mg / g; mice were given five wood grains, detected in serum Deoxyschizandrin content 5,10,20,30 min, respectively 1.07,1.14,0.59,0.51 μ g / ml. Conclusion 5 diesel particles in Schisandra may be absorbed into the body, its rate of absorption and elimination in the body than those faster, consistent with linear kinetics. [Keywords:] 5 diesel particle; Schisandra; pharmacokinetics; high performance liquid chromatography Abstract: Objective To study pharmacokinetics of schizandrinin in Wuchai Particles in mice. MethodsAfter oral administration of Wuchai Particles (2 g / kg) for the mice, the serum was collected at different time points. The components in the Wuchai Particles and serum were analyzed by HPLC to monitor the changes of the schizandrin in serum so as to draw the curve of concentration connected with time. ResultsThe main component in Wuchai Particles was schizandrin; after oral administration of Wuchai Particles, the schizandrin in serum of mice was detected. The mean concentration of schizandrinin was 1.07,1.14,0.59,0.51 μ g / ml respectively at five, ten, twenty, thirty minutes in serum. ConclusionThe schizandrin in Wuchai Particles could be absorbed in mice after oral administration. It could be absorbed and eliminated rapidly