5serotonin transporter gene polymorphism and the incidence of depression sex severity and the relevance of suicidal behavior.docVIP

 PAGE \* MERGEFORMAT 18 5serotonin transporter gene polymorphism and the incidence of depression sex severity and the relevance of suicidal behavior Study: Song Yajing, Zhang, Yin Wang, LUO Jian-xun [Abstract] Objective 5 in Chinese Han population serotonin transporter promoter region (5 HTTLPR) polymorphism and the incidence of depression, sex, severity and suicide are related. Methods The polymerase chain reaction (PCR) amplification Determination of 150 patients with depression and 150 normal controls of the 5 HTTLPR genotypes and alleles, respectively, in the validation of various genotypes with moderate to severe depression, disease, gender and the relevance of suicidal behavior. Results case group SS, LS genotype and S allele frequency was higher (26.0% vs. 20.0%, 52.7% vs. 46.0%, 52.3% vs. 43.0%, P all lt;0.05), compared two groups of gender stratification and female S allele frequency higher (55.3% vs. 43.6%, P lt;0.05), severity of patient group the difference was not statistically significant stratification (Pgt; 0.05), patient group stratified without suicidal behavior compared with suicidal behavior in patients with SS genotype (37.3% vs. 20.2%) and S allele frequency (61.8% vs. 47.5%) were higher than patients without suicidal behavior (P lt;0.05), depression and suicide comparison group is not gender-stratified showed significant differences (Pgt; 0.05), severity of depression and suicide stratified comparison group, severe depression and suicide SS genotype (42.5% vs.18.2%) and S allele frequency (68.7% vs. 36.4%) were higher than that of moderate depression, suicide (P lt;0.05). Conclusion The Chinese Han population, 5 HTTLPR polymorphism and depression-related. S allele may be a susceptibility gene for depression, especially women, SS type may be depression susceptible genotype, S allele may be the risk of depression suicide gene, SS genotypes among patients with depression may be the population at risk of suicide, especially in carrying