6 cases of late-onset autoimmune diabetes mellitus in adult clinical analysis.docVIP

 PAGE \* MERGEFORMAT 6 6 cases of late-onset autoimmune diabetes mellitus in adult clinical analysis [Keywords:] autoimmune diabetes Autoimmune diabetes (latent autoimmune diabetes in adults, LADA should belong to the subtypes of type 1 diabetes, which is characterized as follows: older than 15 years of onset of any age, the incidence is not dependent on insulin within six months, no ketosis occurred more than non-obese at onset , islet B cell antibodies (ICA, GAD and insulin autoantibodies and so often remains positive, with type 1 diabetes susceptibility gene (such as HLA-DR3, HLA-DR4, BW54 and DQ- 131-57-Non-Asp, etc., often accompanied by thyroid and gastric parietal cells and other organ-specific antibodies. LADA early upon diagnosis should be treated with insulin in order to protect the remnants of B cells. American and European data report LADA type 2 diabetes accounts for about 10 % to 15% in non-obese patients with type 2 diabetes has been reported up to 50%, with diabetic patients reported in the literature -2 GAD-Ab positive rate of 14.2%. Late-onset autoimmune diabetes mellitus in adults is the Adult insulin-dependent diabetes mellitus. type of early and severe disease, oral hypoglycemic agents effective after a few years is dependent on exogenous insulin therapy. The following will be encountered 6 cases of clinical analysis. Late onset adult diabetes, also known as latent autoimmune diabetes in adults, more than age 20 to 40 years old, the onset how to drink, eat, polyuria and weight loss, fasting plasma glucosegt; 13.9mmol / L, a spontaneous ketosis tendency. 1 Clinical data 6 patients are in line with WHO diagnostic criteria for the diagnosis of diabetes. 4 males and 2 females, aged 25 to 50 years old, history of diabetes from 1 to 10 years. Onset polydipsia, polyuria, polyphagia obvious weight loss fast , BMI were 24, fasting plasma glucosegt; = 14.1mmol / L, 1 hour after breakfast and 2 hours and C peptide