60Co γ-ray irradiation of rats after whole-brain blood-brain barrier of conventional electron microscope.docVIP

 PAGE \* MERGEFORMAT 16 60Co γ-ray irradiation of rats after whole-brain blood-brain barrier of conventional electron microscope 【Abstract】 Objective: To observe the 60Co  γ-ray irradiation of rats after whole-brain conventional blood-brain barrier (BBB) of the ultrastructural changes. Methods: 20 SD rats were randomly divided into 5 groups, followed by the control group, 10Gy group, 20Gy group, 30Gy group and 40Gy groups of four. 60Co  γ-rays of conventional whole brain irradiation, 2Gy * times  1,5 Ci Zhou  1, with the lanthanum tracer 16h after irradiation, electron microscopy technique to observe chemical changes in the ultrastructure of rat BBB. Results: The control group, lanthanum granules confined to the vascular cavity; 10Gy group of tight junctions, see La particle deposition; 20Gy group of lanthanum particles diffuse distribution of nerve cells in the gap; 30Gy group of lanthanum particles into nerve cells, and distributed in the mitochondria, which endoplasmic reticulum and other cell surfaces; 40Gy group of lanthanum particles diffuse between cells distributed in the brain tissue and cells, showing that capillary endothelial cells and nerve cells lose their normal shape, structural damage. Conclusion: The conventional whole brain irradiation in rats suffered from pathological changes in BBB, and BBB-ray has the reduction and destruction of the function, in the whole brain radiation therapy with the radiation dose during the change in law was changed, with the predictable. Keywords: blood-brain barrier ultrastructure in rats with radiation therapy Blood-brain barrier (BBB) is the exchange of matter between the brain blood  limited system, the maintenance of stability in the brain micro-environment at the same time, it also led to about 95% of the drug can not be effectively integrated through the BBB, leading many of the central nervous system system disease with potential therapeutic value of medication does not play a pha