ABCB4 Genes.docVIP

 PAGE \* MERGEFORMAT 16 ABCB4 Genes [Keywords:] ABCB4 gene function applications Recent years, with ABCB4 gene (ATP binding cassette transporter A4) in-depth study found that, ABCB4 gene and its encoded protein and lipid transport in the bile play an important role. ABCB4 gene encoding the protein is a phosphatidylinositol bile base translocation enzyme, can phosphatidylcholine in the human bile, bile salts emulsify bile, protecting against bile duct epithelial damage [1]. ABCB4 gene mutation may lead to bile duct injury, which led to cholestasis, and then cause many diseases. This article reviews the current research progress. 1 ABCB4 gene and characteristics of the molecular structure ABCB4 gene located on human chromosome 7 in Area 2, often with a sub-zone 1 (7q21.1), began in the first 85,566,809 bp pter, which ends in the first 85,642,313 bp pter. A total of 75,504 bases. Over 74kb and contains 28 exons (average 145bp, range 55, a 259bp), which has the coding sequences of 27 [2]. That the first exon contains the translation of a 26bp non-CpG-rich sequences in ABCB4 cDNA 3.27, expressed as a major part of ABCB4 cDNA. The second exon starting at position equivalent to 6 ATG initiation codon of the gland suo yin position .12 transmembrane domain 8 exons separated Son of the code. transmembrane domain 3 and 4 of the N-terminal half and that they are homologous counterparts 9 and 10 of the C-terminal half that share a single exon. cytoplasmic nuclear past three binding sites are each coding exon (exon 12,13,14, and 25,26,27). exons encoding 28 C-terminal 68 amino acids, which is a non-translated by more than 55 composed of poly A nuclear past The end of the extension. most of the codon between exons interrupted in the coding exons, named exon O-in. from exons 2,5,6, and 8 of the N-terminal and from the Exon 22,23 of the second C-terminal nucleotide codon interrupted after the suits the exon 4 is the first nucleotide after. 2 ABCB4 gene at the