Abnormal changes in tumor micro-satellite research.docVIP

 PAGE \* MERGEFORMAT 33 Abnormal changes in tumor micro-satellite research Abstract The abnormal changes of microsatellite (MSI and LOH) was considered to be another mechanism of tumorigenesis, MSI and LOH affecting the clinical and pathological tumor characteristics of important factors. Micro-satellite detection technology is easy, it can be used to determine prognosis, detection of precancerous lesions. Full text of the nearest few years, changes in tumor micro-satellite anomalies relevant literature, describes MSI and LOH in tumor occurrence and development of the role of its monitoring of precancerous lesions and cancer prevention and treatment of clinical significance. Keywords: Tumor Modern Molecular biology studies have proven that the nature of human cancer is a genetic disease, its mechanism is very complex and involves a series of genetic alterations. Micro-satellites are widely distributed in bio-genome DNA repeat sequences, and a number of important genes closely linked [1]. In recent years, microsatellite analysis as a sensitive genetic indicator of a new hot spot for cancer research is now at home and abroad on the tumor micro-satellite on the abnormal changes of the research are summarized below. A micro-satellites and micro-satellite abnormal changes Microsatellite (microsatellite, MS) is a kind of from 2 to 6 nucleotides consisting of highly polymorphic simple tandem array of DNA sequences, is a class of highly polymorphic genetic markers. Microsatellite sequences located in gene promoter, gene coding region, intron and its exon junction by changing the DNA structure or with the specific protein combination play its role in gene regulation. It is estimated that the human genome carrying at least 100,000 micro-satellites, about 15 000 markers covering all human chromosomes, may be the database access. Microsatellite genomic instability in anomaly is an important molecular markers. Mainly as follows: ① micr