About Qidantongmai of myocardial ischemia - reperfusion injury of interleukin -10.docVIP

 PAGE \* MERGEFORMAT 17 About Qidantongmai of myocardial ischemia / reperfusion injury of interleukin -10 OF: Juan WANG Yue Huang Ye EMERGENCY EMERGENCY IN TRADITIONAL Ma Jing Solutions [Abstract]: Objective Yiqihuoxue Qidan model of myocardial ischemia / reperfusion serum interleukin -10 (IL-10) content to explore the mechanism of myocardial protection. Methods ligation of the left coronary anterior descending artery was prepared myocardial ischemia / reperfusion model in .36 healthy male SD rats were randomly divided into sham operation group, model group, the heart group and Tim Seoul Qidantongmai tablets high, medium and low doses group. ischemia 30 min, reperfusion 2 h, collected whole blood, using ELISA, serum IL-10 levels were observed with HE morphological changes in myocardium, and myocardial ultrastructure with transmission electron microscopy. Results Qidan Tongmai piece of high, medium and low dose group could increase the levels of serum IL-10 to reduce the infiltration of inflammatory cells, reduce the damage of myocardial ultrastructure, including high-dose group was significantly better than the low dose group, and the heart of Seoul and Tim was no significant difference. Conclusion Yiqihuoxue Compound Qidantongmai tablets can promote a large number of endogenous IL-10 release, reduce inflammation, improve impaired myocardial ultrastructure and play the role of myocardial protection. [Keywords:] Qidantongmai tablets myocardial ischemia / reperfusion inflammatory response interleukin -10 myocardial ultrastructure in rats Abstract: Objective To investigate the effects of Qi-reinforcing and blood-activating prescription, Qidan Tongmai Tablet (QDTMT) on the IL-10 in the rat model of myocardial ischemia / reperfusion injury. Methods A model of myocardial ischemia / reperfusion injury was reproduced by ligation of left anterior descending branch of the coronary artery. Thirty-six male SD rats were randomly divided into six groups (n = 6):