Acne Model Research.docVIP

 PAGE \* MERGEFORMAT 32 Acne Model Research [Keywords:] acne; model; risk factors; cell factor Abstract: As the pathogenesis of acne vulgaris is complex, the experimental models of acne vulgaris for different pathogeneses are not the same. So far, the experimental models for acne mainly include in vivo animal models and in vitro models. In vivo animal models mainly include rabbit ear model, golden hamster model, rhino mouse model, Mexican hairless dog model, and so on. In vivo models mainly include keratinocytes culture and sebocyte culture. The experimental methods in the recent years are summarized in this review in order to select proper animal models in experiment and provide experimental platform for the screening of antiacne agnets for prevention and control of acne vulgaris in the future. Keywords:: acne vulgaris; model; etiological factor; cytokines Sebaceous glands, acne is a common disease, its incidence is high, about 90% of adolescents may have varying degrees of acne occurrence. The disease occurs mainly in the face, under varying degrees of skin damage. People to build a model of acne pathology the pathogenesis of acne, to model objects for the experimental induction of acne formation, inhibition of drugs on the acne and other aspects of research. despite all the acne model has its limitations, but for the pathogenesis of acne and the development of clinical application of drugs important. This article aims to experimental methods in recent years, to summarize, in order to facilitate the practical application select the appropriate model. 1 causes acne Acne is a violation of a disease of pilosebaceous unit, in the normal metabolic process, desquamative duct epithelial cells of sebaceous follicles, sebaceous glands secrete sebum, sebaceous follicle population excluded from carrying off bits of which a large number of skin hair follicles can live normal flora, For example, Propionibacterium acnes, Staphylococcus aureus and other ae