Acanthopanax mice of dementia and memory impairment and MDA SOD and the impact of acetylcholinesterase activity.docVIP

 PAGE \* MERGEFORMAT 12 Acanthopanax mice of dementia and memory impairment and MDA SOD and the impact of acetylcholinesterase activity [Abstract] Objective To observe senticosus extract on senile dementia (AD) mouse model of learning and memory impairment and brain biochemical changes in rats. Methods 50 healthy Kunming mice were randomly divided into 5 groups the control group, AD model group, low dose group senticosus, Acanthopanax high dose group, piracetam group .50 d every other day by intraperitoneal injection of aluminum chloride 100 mg / kg in mice, the establishment of the proposed AD model, the platform water maze test and the test methods and biochemical detection methods, extract Acanthopanax AD mice on learning and memory impairment in rats and brain malondialdehyde (MDA content and superoxide dismutase (SOD activity, acetylcholinesterase (TChE activity changes. The results of model group step down test latency, error response rate increased (P lt;0.05, Morris water maze test in mice extended throughout the swim, correct rate of decrease in brain tissue MDA levels increased, SOD activity decreased, TChE activity increased (P lt;0.05. while giving the low and high doses of extract of Acanthopanax ease in varying degrees of learning and memory disabilities and brain biochemical changes (P lt;0.05, P lt;0.01. Conclusion Acanthopanax extract in mice by increasing SOD activity in brain tissue and inhibition of brain activity TChE, AD model mice significantly improved learning and memory impairment and brain biochemical changes in AD have some of the improvement and protection. [Keywords:] Acanthopanax, Alzheimer’s, MDA, SOD, TChE Senile dementia (AD etiology and pathogenesis is not clear so far, but there is no cure AD patients developed drug, currently used in clinical treatment has side effects, efficacy can not be satisfactory (1). Chinese Acanthopanax (Acanthopanax senticosus as Araliaceae, spicy, slightly bitter, warm, non-toxic, with a v