Active oxygen scavenger on the role of optic neuritis in experimental research.docVIP

 PAGE \* MERGEFORMAT 21 Active oxygen scavenger on the role of optic neuritis in experimental research Abstract reactive oxygen species (ROS) is a nervous system demyelination and blood-brain barrier damage media. ROS, including peroxides and nitrous oxide (NO), released by infiltrating inflammatory cells, their metabolites, including hydrogen peroxide (H2O2), Guo (oxidation) nitrite and hydroxyl. In the experimental animal model of optic neuritis occurred in the nervous system demyelination and blood-brain barrier damage, and inflammatory cells, which increases the release of ROS is closely related to active oxygen scavenger, therefore protecting against inflammation of the optic nerve aspects of oxidative stress is particularly important. In this paper, in recent years, active oxygen scavenger on the treatment of optic neuritis in experimental studies are reviewed, and thus on the causes of optic neuritis from the treatment were discussed. Keywords: reactive oxygen species scavenger optic neuritis Progress of the therapy research of the active oxygen scavenger to experimental optic neuritis Abstract Reactive oxygen species (ROS) are mediators of demyelination and disruption of the blood-brain barrier (BBB). Reactive oxygen species include superoxide and nitric oxide, released by infiltrating inflammatory cells, and their metabolites hydrogen peroxide (H2O2), peroxynitrite, and hydroxyl radical. Demyelination and disruption of the BBB occurs in nerve system of the experimental optic neuritis, which has great relationship with the release of the ROS by inflammatory cell. Thus the active oxygen scavenger plays an important role in the protection of the optic nerve in the inflammation from the injury of oxidative stress. The following article is a review of the therapy research of the active oxygen scavenger on experimental optic neuritis, thereby trys to find an active therapy of optic neuritis from the pathogenesis. * KEYW