Active rheumatoid arthritis Correlation of pulmonary function changes.docVIP

 PAGE \* MERGEFORMAT 17 Active rheumatoid arthritis Correlation of pulmonary function changes Of: Lei Wan, Mrs, Shengchang Jian, Xie Xiuli [Abstract] Objective To study the activity of rheumatoid arthritis (RA) patients with changes in lung function. Methods 60 patients with active RA were divided into two groups and decreased lung function normal lung function were observed 2 groups of clinical symptoms and signs, laboratory index, health index (HAQ) points, disease activity score (DAS-28) and regulating T cells (Treg) changes in lung function detected by pulmonary function of patients with active RA. Results 60 cases of active RA patients, pulmonary features reduce the 42 patients (70%), normal lung function, 18 patients (30%). Compared with normal lung function, lung function decreased significantly lower hemoglobin group (P lt;0.05), the difference between small airway obstruction was 60% or more , differences in ventilation rate of 20% to 30%, joint swelling points, 15 m walking time, two-hand grip, fatigue weakness and X-phases were significantly increased (P lt;0.05 or P lt;0.01). Spearman correlation analysis, active RA patients with lung function parameters and joint pain score, joint tenderness score, two-hand grip, white blood cells, red blood cells, CD4 + Treg, CD25 + Treg, CD4 + CD25 + Treg, CD4 + CD25 + CD127-Treg were positively correlated (P lt;0.05 or P lt;0.01), and joint swelling score, duration of morning stiffness, 15 m walking time, eat less bloating, symptoms total score, IgM, IgA, complement C3, rheumatoid factor, X ray showed a negative correlation between stages (P lt;0.05 or P lt;0.01). Conclusion active in the pathogenesis of RA patients with a certain degree of lung function, lung function changes in small airway obstruction, ventilatory dysfunction, mainly, and with clinical symptoms, signs and laboratory parameters were highly correlated , which is why periodic dynamic observation of pulmonary function in patients with RA, t