Advanced breast cancer preoperative neoadjuvant chemotherapy for 86 patients.docVIP

 PAGE \* MERGEFORMAT 5 Advanced breast cancer preoperative neoadjuvant chemotherapy for 86 patients Author: Xue Feng Jie, DAI Zhi-jun, Wang Xijing, Xing-Huan Xue, Hua-Feng Kang, Xiao-Xu Liu, Guan Hai-Tao, ZHANG Shu-Qun [Keywords:], breast cancer Preoperative neoadjuvant chemotherapy for 86 patients with advanced breast cancer [Abstract] AIM: To evaluate the clinical significance of CEF regimen as neoadjuvant chemotherapy for advanced breast cancer. METHODS: Eightysix patients with stage Ⅱ b Ⅲ breast cancer were treated with CEF regimen for 2 treatment cycles with each lasting for 28 d. According to the effect standard and toxic grading standard suggested by WHO, the efficacy and safety were evaluated. The patients received cyclophosphamide (CTX) 500 mg/m2 on day 1 and 8, epirubincin (EPI) 50 mg/m2 on day 1, and 8, and 5fluorouracil (5Fu) 500 mg/m2 on day 1 and 8. RESULTS: The cancer degraded in 35 (40.7%) patients and the overall response rate (RR) of the primary tumor was 47.7% (43/86). Four cases had complete response (CR), 37 cases partial response (PR) and no disease progressive (PD) case. For axillary lymph nodes, the overall response rate (RR) was 61.4% (51/83). For clinically palpable axillary lymph nodes which had been found in 83 patients before treatment, 28.9% (24/83) became inpalpable. The major toxicity included leukopenia, gastroenteric reactions and alopecia. CONCLUISON: Neoadjuvant chemotherapy with CEF regimen for advanced breast cancer is effective and tolerable and therefore, is warranted for wide use. [Keywords] breast neoplasms; neoadjuvant chemotherapy; clinical effect [Abstract] Objective: To investigate the neo-adjuvant chemotherapy for advanced breast cancer clinical significance. Methods: 200001/200412 application of CEF programs on the 86 cases of Ⅱ b Ⅲ breast cancer patients with neoadjuvant chemotherapy. Cyclophosphamide (CTX) 500 mg/m2, d1 , d8; epirubicin (EPI) 50 mg/m2, d1, d8; fluorouracil (5Fu) 500 mg/m2, d1, d8. 28 d