Advances in treatment of unstable angina.docVIP

 PAGE \* MERGEFORMAT 12 Advances in treatment of unstable angina [Keywords:] Advances in the treatment of unstable angina pectoris Unstable angina (unstable angina pectoris, UAP) is between exertional stable angina and acute myocardial infarction and sudden death between the clinical manifestations, including the initial issuance of angina, worsening angina pectoris, Resting angina with ischemic electrocardiographic changes and angina pectoris early after myocardial infarction. Its main cause is the development of coronary atherosclerosis, causing progressive coronary artery stenosis, platelet aggregation and vasoconstrictor substances produced thromboxane A2, normal endothelial cells by anti-aggregation substances such as prostacyclin, tissue plasminogen activator and endothelial relaxation factor source concentrations decrease, causing coronary artery contraction, as well as stenosis increased resistance to dynamic coronary occlusion and increased thrombosis, coronary artery spasm. Because of its unique pathophysiology and prognosis, if not properly and timely treatment, patients may develop acute myocardial infarction. UAP Treatment aims to relieve symptoms and reduce the incidence of cardiac events and improve prognosis and quality of life, and positive and reasonable treatment is to reduce the risk of myocardial infarction and death in the key. now UAP progress of treatment are summarized below. A routine treatment 1.1 nitrates through expansion and increased epicardial coronary artery collateral flow to increase the blood supply and oxygen supply, as well as to reduce the systemic circulation through the expansion of wall tension and oxygen demand, can relieve angina, increased exercise tolerance, improve myocardial ischemia. In UAP, the need to intravenous infusion of nitroglycerin, dose decreased from 5 ~ 10 g / min, every 5 ~ 10 min dose adjustment based on symptoms, until the angina relief or adverse reactions. increase the dose should pay