AGP pairs of nude mice bearing human laryngeal cancer in vitro.docVIP

 PAGE \* MERGEFORMAT 10 AGP pairs of nude mice bearing human laryngeal cancer in vitro Liu Guolong Mao Haibo Wu Yong Weng Cheng Yin Wu Hongying [Abstract] Objective To use human laryngeal transplantation model in nude mice, and electron microscopy to study the AGP rationale of anti-tumor effect and possible mechanism. Methods in human laryngeal transplantation model in nude mice, observation AGP (AGP) with the control group of tumor suppressor rate; electron microscopic observation of ultrastructural changes of AGP-induced cancer. Results AGP in nude mice with transplanted human laryngeal significantly inhibited, with an average tumor inhibition rate was 47.21 percent, to nude mice bearing cancer, no significant inhibition of weight gain and transmission electron microscopy AGP observed a large number of tumor cells can induce apoptosis and necrosis of a small amount of direct . Conclusion AGP on human laryngeal significantly inhibited apoptosis induced by cancer cells is the main mechanism for the growth of experimental animals had no significant effect. [Keywords:] AGP nude mice xenograft model of human laryngeal cancer Abstract: ObjectiveTo study the anti-tumor effect of AGP on nude mice inplanted with human laryngeal carcinoma cells and its machanism.MethodsThe tumor inhibitory rate was measured on nude mice implanted with human laryngeal carcinoma cells and the super-microstructure change of cancer cells was observed by transmisssion electron microscope.ResultsThe inhibitory rate of the implanted cancer in AGP group was 47.21%, transmission electron microscope observation results showed that AGP induced cell apoptosis more than direct necrosis.ConclusionAGP can inhibit the growth of implanted human laryngeal carcinoma cells by inducing apoptosis. AGP has no side effect on growth of nude mice in this trial. Keywords:: AGP; Nude mice model; Human laryngeal carcinoma Larynx (laryngeal carcinoma) is a common head and neck cancer. At present the treatment