Aglycone isoflavone pills and tablets in rats in vivo bioavailability study.docVIP

 PAGE \* MERGEFORMAT 11 Aglycone isoflavone pills and tablets in rats in vivo bioavailability study Of: Yang, Donghai Song Jing Ren Dongdong Zhou Tianhong Roth [Abstract] Objective To study the isoflavone aglycone pills and tablets of the pharmacokinetics and relative bioavailability. Methods SD rats as experimental animals, using high performance liquid chromatography isoflavone aglycone filling single dose pills and tablets the stomach of rats after administration of blood concentration. with 3P97 pharmacokinetic software for data processing, calculation and analysis of pharmacokinetic parameters and relative bioavailability. isoflavone aglycone pills results: AUC was 46.30 g min mL-1, cmax was 0.89 g mL-1, tmax was 18.03 min; tablet: AUC was 36.01 g min mL-1, cmax was 0.41 g mL-1, tmax was 31.43 min, relative pills in the relative bioavailability of the tablet is 128%. Conclusion isoflavone aglycone pills, tablets are in line with one compartment model, pills higher than the tablet bioavailability. The Pill for the isoflavone aglycone provides a basis for development. [Keywords:] isoflavone aglycone pills; isoflavone aglycone tablets; performance liquid chromatography; pharmacokinetics; relative bioavailability Abstract: Objective To investigate the pharmacokinetic and relative bioavailability of isoflavone aglycone dripping pills and tablets in healthy SD Rats, and evaluate the pharmacokinetic effects of the two dosage forms of isoflavone aglycone. Methods 36 SD rats were intragastrically administered with the suspension solution of isoflavone aglycone dripping pills and tablets at single dose, and changes in plasma concentration were determined by HPLC. Pharmacokinetic data were processed with 3P97 software and the pharmacokinetic parameters and relative bioavailability were calculated. Results For dripping pills of isoflavone aglycone: AUC = 46.30 g min mL-1, Cmax = 0.89 g mL-1, Tmax = 18.03 min; and for tablets of isoflavone aglycone