Application renal transplantation rabbit anti-human thymocyte immunoglobulin efficacy.docVIP

 PAGE \* MERGEFORMAT 9 Application renal transplantation rabbit anti-human thymocyte immunoglobulin efficacy Study: Wang Weigang Dixiu Yu Sun Ling Di Chengwei [Keywords:] kidney transplantation; rabbit anti-human thymocyte immunoglobulin; Application Rabbit anti-human thymocyte immunoglobulin (ATG) is a selective immunosuppressive agent, a major role in T lymphocytes, leading to cell failure, resulting in immunosuppression to the relief of symptoms (1,2). Can prevent and reverse most of the early stage of rejection, immediately after renal transplantation can significantly reduce the prophylactic use of ATG after the occurrence of early acute rejection. I applied ATG Division renal transplant patients the prevention and treatment of early stage of rejection, no 1 patient due to serious adverse reactions and withdrawal, renal function after the application. 1 Clinical data 1.1 General Information January-October 2009, the Center treated the application of ATG in kidney transplant patients 31 patients, 21 males, 10 females, aged 45 to 60 years, mean age 55.1 years, mean hospital stay 13.5 d, graft 28 patients before induction with ATG, rejection drug treatment in 3 cases, mean follow-up of 6.5 months, 31 patients were stable renal function. 1.2 ATG to use 1.2.1 inducing drugs on the transplantation day administration of 4 h before surgery, general dose 1 ~ 1.5 mg kg-1 d-1, adding 0.9% sodium chloride 500 ml 6 ~ 8 h pump. Infusions before and after 5 mg dexamethasone intravenously, given before infusion of 25 mg intramuscular injection of promethazine hydrochloride in prevention of adverse reactions during the continuous application of 3 d. immunosuppressant drugs reduce it, after stopping the gradual resumption of normal dose. 1.2.2 rejection drug therapy based on clinical manifestations and pathological diagnosis of renal biopsy renal rejection. Mild rejection medication with drug induced; heavy dose of rejection is usually 1.5 mg kg-1