Aqueous extract of Scutellaria Mechanism of antipyretic.docVIP

 PAGE \* MERGEFORMAT 12 Aqueous extract of Scutellaria Mechanism of antipyretic Of: Xu Shan, Songlin Li, Yang Xin, Song Dan brother, Meng Qinggang [Abstract] Objective To investigate the aqueous extract of Scutellaria dry yeast antipyretic effect of induced fever in rats. METHODS established animal model of dry yeast induced fever was observed aqueous extract of Scutellaria rat rectal temperature of heating, large radioimmunoassay hypothalamic cyclic adenosine monophosphate (cAMP), interleukin-1β (IL-1β) and brain VSA arginine vasopressin (AVP), serum IL-1β content. baicalin aqueous extract of the results can significantly dry yeast induced fever in rats reduced the hypothalamic IL-1β, cAMP content and VSA AVP content in brain tissue, compared with model group, P lt;0.05, the maximum body temperature of rats increased hypothalamic IL-height 1β, cAMP content and VSA brain AVP levels were positively correlated (P lt;0.05). Conclusion baicalin aqueous extract can reduce pyrogenic cytokine IL-1β in vivo Wenzhong Shu content, reducing the central heating medium cAMP, content, promoting the release of central antipyretic AVP media. [Keywords:] aqueous extract of Scutellaria, antipyretic, mechanism, animal model Abstract: Objective To research the mechanism of aqueous extract of Radix Scutellariae in relieving fever of model rats. Method The fever model rats were made by dry yeast. Rectum temperature (ΔT / ℃) was observed, and serum IL-1β, hypothalamus cAMP and IL-1β, ventral septal area AVP were detected by RIA. Results Aqueous extract of Radix Scutellariae decreased IL-1β and cAMP content of hypothalamus, and AVP content of ventral septal area significantly (compared with model group, P lt;0.05). There were positive correlativity between maximum height of temperature and IL-1β, cAMP content of hypothalamus, and AVP content of ventral septal area (P lt;0.05). Conclusion Radix Scutellariae can decrease the content of IL-1β and cAMP in temperature center, a