AQP1 in giant cell tumor of the expression and significance.docVIP

 PAGE \* MERGEFORMAT 12 AQP1 in giant cell tumor of the expression and significance [Abstract] Objective To study the water channel protein 1 (aquaporin 1, AQP1) in giant cell tumor of the distribution and giant cell tumor of bone group and control group differences in the expression and to identify AQP1 levels in giant cell tumor of bone in the expression of differences, to determine AQP1 in giant cell tumor of the liver. Methods 42 cases of giant cell tumor of bone specimens and 24 cases of control group specimens, using immunohistochemistry, were observed in the tissue distribution of AQP1, automatic image analysis detected the expression of AQP1 in both groups. Results a) The immunohistochemical staining showed: AQP1 expressed in all tumor specimens and small capillary endothelial cells, AQP1 expression in giant cell tumor of the majority of tumor cells, AQP1 In the control group, no expression or expression is very weak, b) automatic image analysis system from the average optical density in the two groups differ significantly (P lt;0.01), AQP1 in giant cell tumors with high expression, c) AQP1 expression in giant tumor grade and grade giant cell tumor of bone were significantly different (P lt;0.01), and AQP1 expression in giant cell tumor of bone no difference between the other levels (Pgt; 0.05). Conclusion Most of the giant cell tumor of bone tumors cells of unknown causes high expression of AQP1, AQP1 in giant cell tumor of bone is highly expressed in bone indicates that the biological behavior of giant cell tumor of the role, AQP1 expression in giant cell tumor grade and grade giant cell tumor of bone differences significant, suggesting that AQP1 may have a case of giant cell tumor of bone and level of bone giant cell tumor of the role. [Keywords:] giant cell tumor of the water channel protein 1 immunohistochemistry Abstract: Objective To study expression level and distribution of aquaporin 1 (AQP1) in giant cell tumor of bone (GCT) gro