Artemisinin and its derivatives a new class of anti-tumor compounds target research.docVIP

 PAGE \* MERGEFORMAT 26 Artemisinin and its derivatives a new class of anti-tumor compounds target research 【Abstract】 Objective of artemisinin and its derivatives are a new class of anti-tumor compounds, the target of its role in recent years, a comprehensive overview. Methods access at home and abroad in recent years, a large number of relevant literature. The results mechanism of action may be related to block tumor cell cycle, regulate signal transduction of tumor cells to induce apoptosis of tumor cells and other targets related. Conclusion on the chemical structure of artemisinin and its derivatives have a certain novelty, show multi-target anti-tumor effect, multi-link, multi-effect characteristics of its anti-tumor targets and mechanisms of action, side effects such as in-depth study, it may into a clinical value of anti-cancer drugs. Keywords: artemisinin; target; molecular mechanism of Artemisia annua, also known as fragrant, bitter Artemisia, Artemisia sticks, in order to Asteraceae Artemisia annua, wild all over the country, rich in resources. ACTs (artemisinin) was first introduced by China’s pharmaceutical workers in the early 20th century, 70 extracted from the Artemisia annua and effective antimalarial ingredient, as a peroxide-containing groups within the sesquiterpene lactone compounds in clinical practice for the treatment of falciparum malaria and cerebral malaria, is to identify WHO’s global malaria control and effective drugs, but also China’s only drugs with independent intellectual property rights. Artemether (artemether), Artemisia ether (arteether), artesunate (artesunate) and dihydroartemisinin (dihydroartemisinin) and so its main derivatives. Shanghai Institute of Materia Medica Chinese Academy of Sciences in 1991, Deng was first reported by Ding-An artemisinin derivatives on murine leukemia P388 cells were significantly inhibited, and then set off domestic and foreign scholars of artemisinin and its derivativ