Aqueous extract of Prunella ICR mice on the impact of postprandial hyperglycemia.docVIP

 PAGE \* MERGEFORMAT 12 Aqueous extract of Prunella ICR mice on the impact of postprandial hyperglycemia Of: Guo Ying, Gui-mei, Gao Ming Zhuang Lingling Ding Ting, Wu Huiping [Abstract] Objective: To study the aqueous extract of Prunella normal and alloxan diabetic ICR mice postprandial hyperglycemia. Methods: Two groups of ICR mice containing Prunella 22.0,11.0,5.5 g (kg times ) -1 orally observe the effects of starch tolerance test; Periodic Acid Schiff stain (PAS) observed in liver, muscle glycogen content, HE staining of liver and kidney structure. Results: Prunella water extraction material can reduce the normal and alloxan diabetic ICR mice postprandial hyperglycemia. ICR mouse liver PAS staining. livers, kidneys, HE staining was normal. Conclusion: Water extract of Prunella vulgaris by promoting glycogen synthesis may reduce the normal and alloxan diabetic ICR mice postprandial hyperglycemia, increased the starch tolerance, while the liver and kidney tissue had no injury. [Keywords:] Prunella; starch tolerance test; postprandial hyperglycemia; ICR mice [Abstract] Objective: To study the effects of the water extract of Prunella vulgaris L.on postprandial hyperglycemia ICR mice. Methods: ICR mices were orally administered the water extract of Prunella vulgaris L. of 22.0, 11.0, 5.5 g kg-1 once to observe its effects on the amylum tolerance test. Periodic acid Schiff reagent (PAS) was used to determine the contents of liver and muscle glycogen.HE staining was performend to observe the changes in the liver and kidney tissue structures. Results: The water extract of Prunella vulgaris L. decreased the postprandial hyperglycemia for the amylum tolerance test in normal and alloxan diabetes mellitus ICR mice. The liver of ICR mice showed posivtive PAS staining. No changes were found in the liver and kidney tissue by HE staining. Conclution: The water extract of Prunella vulgaris L. could promote the hepatic glycogen synthesis, decrease the postpran