Ara-C and the stability of 7 infusions.docVIP

 PAGE \* MERGEFORMAT 9 Ara-C and the stability of 7 infusions Abstract cytarabine hydrochloride with 7 commonly used infusions were observed after the appearance of compatibility, pH, and content changes, using ultraviolet spectrophotometry Ara-C concentration. Results 25 ℃ , 37 ℃ placed 24h, the compatibility of non-color change, pH, no significant changes. Cytarabine hydrochloride in balancing the fluids and sodium bicarbonate injection has declined more. Dosage (μ g / ml) Measured the amount of (μ g / ml) Recovery (%) Mean (%) 20.000 19.930 99.65 99.26 10.000 9.952 99.52 (RSD = 0.57%) 5.000 4.931 98.61 Reposted elsewhere in the paper for free download Temperature Infusion 2h 4h 6h 8h 24h 25 ℃ NS 101.60 100.10 99.14 98.62 97.35 GS-5 100.60 99.69 99.85 98.69 96.75 GS-10 99.98 99.16 99.40 98.25 97.64 GNS 99.83 99.62 97.34 96.26 94.60 Balanced Salt Solution 99.10 98.24 96.48 95.33 93.21 Low Right 100.80 99.87 99.12 98.22 95.20 SB 98.80 97.10 95.42 93.80 93.28 37 ℃ NS 100.70 99.42 99.83 96.44 96.12 GS-5 101.40 99.46 99.82 98.77 95.16 GS-10 98.47 99.35 98.25 97.10 96.61 GNS 99.64 99.43 98.66 97.23 96.97 Balanced Salt Solution 98.87 97.21 96.10 94.28 92.95 Low Right 101.20 99.92 98.40 97.63 96.40 SB 98.50 96.24 95.82 92.55 90.73 3 Discussion Ara-C and balance fluid and SB compatibility more content decreased after 24h, suggesting appropriate fluids or basic drugs and basic compatibility. SB compatibility solution pH increased slightly, probably due to the slow decomposition of the Department of SB’s own 〔 4〕 . References 〔 1〕 Chen Xin Qian, Kim Yu-editor. Society for Pharmacology. 14th edition. Beijing: People’s Health Publishing House, 19:514 〔 2〕 Chinese Pharmacopoeia 2000 edition. 2 .2000:620 Ren Zhiqiang, 〔 3〕 . Pentoxifylline infusions in stability. J