Article V factor and anti-phospholipid antibodies are children the pathogenesis of myocardial ischemia important risk factor for stroke.docVIP

 PAGE \* MERGEFORMAT 6 Article V factor and anti-phospholipid antibodies are children the pathogenesis of myocardial ischemia important risk factor for stroke [Abstract] Objective: To study the first V factor (FVL) and anti-phospholipid antibodies (APLA) and child relationship between the incidence of myocardial ischemic stroke. Methods: The disease group and control group were carried out coagulation, immunoassay. Results: Heterozygous FII G20210A and homozygous MTHFR677T with an increased risk of stroke incidence has nothing to do, and FVL heterozygous gene cause the risk of stroke incidence is about 5 times. 5 cases of children suffering from stroke, at the same time there are two times thrombophilia records. Conclusion: The children suffering from stroke, compared with the control group more likely to have thrombo-embolism, may be noted that FVL and APLA was caused by a significant factor in stroke onset. [Keywords:] Myocardial ischemia; Article V factor; anti-phospholipid antibody; thrombosis; Children’s Stroke Children, the incidence of stroke was significantly lower than adults, accounting for about 0.63 ~ 1.2/100000 [1]. The majority of children caused by myocardial ischemia and stroke factor is the occlusion of blood vessels thrombosis [2]. Hereditary protein S (PS) and protein C (PC) deficiency and children, the relationship between the onset of mid-term wind there is a dispute [3]. Studies have shown that lack of PS and PC and stroke related. Thrombosis precursor polymorphism [4], such as FVL of 506 amino acid residues of the glutamate-fold L-arginine substitution and FII G20210A in G  to  A transfer is found to be common VTE risk factors. In pediatric stroke, arterial thromboembolism, and some reports in the growth of FVL has been observed, but these data can not be confirmed in other studies. Similarly, FII G20210A and children’s relations with the wind period there is a dispute [5]. In addition, MTHFR nucleotide 677 (C677T) polymorphism hom