Armored grass dimethylnitrosamine-induced inhibition of rat liver fibrosis.docVIP

 PAGE \* MERGEFORMAT 14 Armored grass dimethylnitrosamine-induced inhibition of rat liver fibrosis Of: Zhang Ji Da, Wen Chengping, Fan Yongsheng [Abstract] Objective To observe the inhibition of ethanol extract of grass armored dimethylnitrosamine-induced liver fibrosis effect and its mechanism. Methods dimethylnitrosamine-induced liver fibrosis in rats, with high, medium and low dose (12.6,4.2,1.4 g / kg) alcohol extract of grass armored intervention treatment, and were compared with colchicine, liver function test, serum hyaluronic acid (HA), layer mucin (LN and procollagen amino terminal peptide (PC ), liver hydroxyproline (Hyp) content and liver histopathological changes. Results armored grass high, medium and low doses of serum alanine aminotransferase (ALT) and high-dose group armor grass serum aspartate aminotransferase (AST) levels compared with the model group was statistically significant (P lt;0.05), armored grass of liver tissue Hyp dose group were significantly lower than model group (P lt;0.05). Drafting of the doses of armored serum HA, LN, PC were significantly lower than the model group, the difference was statistically significant (P lt;0.05). armored grass high, medium and low dose group significantly reduced liver fibrosis, and model group, the difference was statistically significant (P lt;0.05). Conclusion armored grass on dimethylnitrosamine-induced liver fibrosis in rats significantly inhibited, and its mechanism may protect the liver cells and inhibition of collagen synthesis related. [Keywords:] armored grass, hepatic fibrosis, dimethylnitrosamine Abstract: ObjectiveThe aim of this study was to observe the inhibitive effects of the extract of Cassia mimosoides Linn. On dimethylnitrosamine-induced hepatic fibrosis in rats and to explore the action mechanism. MethodsIntervention treatment with the extract of Cassia mimosoides Linn. Was explored in the rats with dimethylnitrosamine-induced hepatic fibrosis at the high, inter