Astragalus Combination fangchi nephrotoxicity metabonomics.docVIP

 PAGE \* MERGEFORMAT 12 Astragalus Combination fangchi nephrotoxicity metabonomics OF: Ming-Liang Qi Xie Ni Cheng Yan Xianzhong Zhang Yanxia [Abstract] using metabonomics fangchi rat and its prescription of oral Astragalus decoction of metabolic profiles of urine after the changes of gram fangchi Attenuation of the kidney. [Methods] Male wistar rats were 24 divided into normal control group, group fangchi widely Qi group, n = 8. fangchi group at 8.1g/kg, 9.1g/kg wide Qi group by gavage, the control group fed with an equal volume of distilled water. After continuous administration 4w, 24h urine collection rats were measured 1H NMR spectra of urine, blood do BUN, SCr test, take the kidneys for histopathological examination. [results] 4w administration, the group fangchi BUN, SCr significantly increased (P lt;0.01, kidney showed obvious pathological changes, wide SCr level of Qi group had significantly lower anti-wider (P lt;0.05, and degree of renal lesions have a wider group of anti-light. urinary metabolic profiles by principal component analysis showed that urinary fangchi citric acid, 2-ketoglutarate, ma niu salts, glucose content decreased, TMAO, creatine content increased creatinine. Guang Qi group changes in these metabolites were reduced to varying degrees. [Conclusion] 4w fangchi delivery can cause significant damage to kidney function, compatibility Astragalus against certain of its damage. [Keywords:] fangchi, astragalus, Chinese medicine compatibility, renal toxicity, metabolomics, nuclear magnetic resonance, pattern recognition [Objective] Study the metabonomics profile of in the urine samples of rat dosed with decoctions of Aristolochia fangchi and it’s compatible with Astragali radix. To found that the inhibition effect on Nephrotoxicity of Aristolochiae fangchi by compatible with Astragali radix. [Method] 24 Male Wistar rats were divided to three groups, the G group were administrated by 8.1g/kg-1 of Aristolochia fangchi, the GQ group