As2O3 - Mn0.5Zn0.5Fe2O4 composite nanoparticles and its breast cancer cell proliferation and apoptosis of.docVIP

 PAGE \* MERGEFORMAT 15 As2O3 / Mn0.5Zn0.5Fe2O4 composite nanoparticles and its breast cancer cell proliferation and apoptosis of [Abstract] Objective: Preparation of As2O3 / Mn0.5Zn0.5Fe2O4 composite nanoparticles to study the thermal effects of chemotherapy on breast cancer treatment. Methods: The modified chemical precipitation impregnation As2O3 / Mn0.5Zn0.5Fe2O4 composite nanoparticles, through the transmission and scanning electron microscopy, energy dispersive spectroscopy, atomic fluorescence spectrometer to characterize; detection As2O3 / Mn0.5Zn0.5Fe2O4 release level and composite nanoparticles in an alternating magnetic field heating capacity; by MTT assay and flow cytometry detected chemotherapy, thermotherapy and heat treatment of breast cancer chemotherapy. Results: The diameter of the composite nanoparticles 20 ~ 40nm; composite nanoparticles in vitro temperature to achieve effective treatment of tumors temperature (41 ~ 46 ) ; slow release, 48 h drug release was 14.67%. Conclusion: The modified chemical precipitation impregnation method can be successfully prepared As2O3 / Mn0.5Zn0.5Fe2O4 composite nanoparticles, in vitro experiments show that the composite nanoparticles alternating magnetic field hyperthermia combined breast cancer cells with strong growth inhibition and apoptosis induction. [Keywords:] As2O3 / Mn0.5Zn0.5Fe2O4; nm; heat chemotherapy; breast cancer Diagnosis and treatment of cancer medicine has been trying to overcome the problem, along with the development of medical standards, people of new methods of cancer treatment has been forward to the molecular and atomic levels In 1996, German scholar Jordan [1] found that nano micron scale magnetic particles than the particles can produce more heat, magnetic fluid hyperthermia is proposed (magnetic fluid hyperthermia, MFH) of new technologies. the present study, the modified chemical precipitation were prepared by impregnation As2O3 / Mn0.5Zn0.5Fe2O4 nanocomposite grain, will