Astragalus Panax different dose combinations on mesangial cell proliferation.docVIP

 PAGE \* MERGEFORMAT 12 Astragalus Panax different dose combinations on mesangial cell proliferation Of: Liu Mingping IN TRADITIONAL Wuqing Guang, Wei Qing goods [Abstract] Objective To study oral prescription Tongmai Astragalus, Panax different dose combinations on mesangial cell proliferation, the best compatibility screening dose. Methods Serum pharmacological method, pass the compatibility of different doses of preparation veins containing serum in vitro was detected on glomerular mesangial cells (GMC) proliferation. Results Tongmai oral solution, Astragalus, Panax serum containing different doses of compatibility, both in normal culture conditions or in the lipopolysaccharide ( LPS) stimulated conditions, were some of GMC proliferation inhibition ratio of the dose groups compared with serum inhibition Tongmai than 3:1 Tongmai 6:1,1.5:1 containing serum. Conclusion of the original parties Astragalus, Panax dose ratio of 3:1 has a certain rationality. [Keywords:] Astragalus Panax combination on glomerular mesangial cells ABSTRACT: Objective To study the effect on proliferation of glomerular mesangial (GMC) cell by the dose compatible proportion between Radix Astrsgali and Radix Notoginseng in Tongmai Oral Liquid (TMOL) so as to select the optimal dose proportion. Methods We used serological pharmacological methods to prepare Decoction of Tongmai of different dose proportions and assay its effect on the proliferation of GMC to confirm the best dose compatible proportion between Radix Astrsgali and Radix Notoginseng of Decoction of Tongmai. Results Both TMOL and the different proportions between Radix Astrsgali and Radix Notoginseng (6 : 1, 3:1, 1.5:1) of Decoction of Tongmai could inhibit the proliferation of GMC cultured either in fetal cow serum (FCS) or in FCS plus lipoplysaccharide. The inhibitory effect of Decoction of Tongmai (3:1) group was better than both Decoction of Tongmai 6:1 and Decoction of Tongmai 1.5:1. Conclusion The dose compati