Astragalus polysaccharide on tumor-bearing mice IL 2 IL 6 IL 12 and TNF α levels.docVIP

 PAGE \* MERGEFORMAT 9 Astragalus polysaccharide on tumor-bearing mice IL 2 IL 6 IL 12 and TNF α levels OF: Ming-Hua Liu Rong Li Mao Xiao Shunhan Renmei Ping [Abstract] Objective: of Astragalus polysaccharide on tumor growth and tumor-bearing mice with cytokine levels. Methods: The mouse hepatoma H22 and sarcoma S180 in mice transplanted tumor model to examine the APS anti-tumor activity in vivo, using APS ELISA assay of serum tumor-bearing mice on interleukin 2 (IL 2, interleukin 6 (IL 6, interleukin 12 (IL 12, tumor necrosis factor-@ (TNF @ levels. Results: AM polysaccharides in the 50,100 mg · kg-1, the mouse hepatoma H22 on the inhibitory rates were 32.84%, 45.09%, the inhibition of mouse S180 sarcoma were 36.55%, 50.35%, and can enhance the tumor-bearing the spleen index and thymus index, APS can enhance the tumor-bearing mice serum cytokine IL 2, IL 6, IL 12 and TNF @ level. CONCLUSION: APS has a significant anti-tumor activity in vivo, which may be and enhance the body’s immune function. [Keywords:] APS, tumor-bearing mice, cytokine Astragalus Astragalus is a plant for the legume to the roots of medicine, only contained in the lt;lt;Shen Nong’s Herbal Sutra “gt;, of tepid, sweet, with qi solid form, reducing blood pressure, diuretic swelling, pus care drugs, gather raw sores muscle and other effects, can enhance immune system function, promote metabolism, Liver Lee kidney, anti-aging delay decay [1]. This experiment APS in vivo antitumor effect of a preliminary study to expand the APS in clinical oncology Treatment of experimental evidence available. 1 Materials and methods 1.1 Drugs and reagents APS drugs by the Luzhou Medical Institute, prepared before use and diluted with saline, cisplatin (DDP injection (Gejiu Biological Pharmaceutical Co., Ltd., batch number: 070601, mouse IL 2 ELISA kit, mouse IL 6 ELISA kit, mouse IL 12 ELISA kit and mouse TNF @ ELISA kits were purchased from U.S. Biological Engineering Co., Ltd. crystal. 1.2