Auger electron emission application of radionuclide targeted therapy.docVIP

 PAGE \* MERGEFORMAT 5 Auger electron emission application of radionuclide targeted therapy Auger electron cytotoxicity and its application in targeted radiotherapy within the application, especially for 125I and 125I-Idoxuridine (IUdR) of long-term study, so that people’s understanding in this area has been a breakthrough. International Atomic Energy Agency (IAEA) in 1976 launched the international cooperation in research projects to study the 125I-UdR treatment of human tumor mechanisms, the feasibility and practical value [1]. J Nucl Med (USA) in 1996 reported supplement the system in this field are reviewed. 1, Auger electron emission of radionuclides Auger electron emission of radionuclides a lot can be divided into three categories [2]: ① γ -ray emission Auger electron emission at the same time there are 51Cr, 67Ga, 75Sr, 80Brm, 99Tcm, 114Inm, 115 Inm, 123I, 125I, 193Ptm and 195Ptm, etc.; ② α -ray emission Auger electron emission at the same time there are 212Bi, 211At, and 255Fm; ③ positron emission Auger electron emission at the same time there are 73Se, 94Tc, and 124I. 2, Auger electron physics properties Of radionuclides in the electron capture or internal conversion in the process of Auger electron emission [2]. Decay of different radionuclides emitted Auger electron has a different energy, most of which Auger electron energy of 20 ~ 500 eV, within the range of biological tissue 1 ~ 10 nm, linear energy transfer (LET) of 10 ~ 25 keV / μ m, a high-LET, and LET α particles close to [3]. Such as the decay of 125I is divided into two steps, the first step is an electron-trapping, the first step 2 is an inner transformation, in this two-step process, respectively, the same amount of emitted Auger electron, a total of 22. The 123I was first through the electron capture Auger electron emission 11, and then fired through the isomer γ -photon energy conversion. Therefore, 125I decay time the number of electrons produced by Auger 2 times 12