Atherosclerosis and the relationship between inflammation Progress.docVIP

 PAGE \* MERGEFORMAT 23 Atherosclerosis and the relationship between inflammation Progress [Keywords:] atherosclerosis, inflammation, coronary artery disease On atherosclerosis (AS) had the pathogenesis of several theories: theory of lipid infiltration, platelet aggregation and thrombosis theory, theory of monoclonal smooth muscle cell proliferation and immune response theory and damage theory, where theory and the damage response This developed from the inflammatory theory, a more comprehensive explanation of the development process of the formation of AS. now that, AS outcome from the development to the whole process is a chronic inflammatory process, numerous inflammatory cells and inflammatory mediators involved (1) However, the process of inflammation, the mechanisms involved in AS has not yet been fully elucidated, current research has focused on a variety of inflammatory cells, mediators and mutual relations. 1, various types of cells in the role of AS AS lesions exist in endothelial cells, macrophages, lymphocytes, smooth muscle cells and mast cells and other primary cells, the current study with AS more and more closely the occurrence and development of relations between the inflammatory cells are monocytes / macrophages and lymphocytes . 1.1 endothelial cells Vascular endothelial cell damage and dysfunction is part of AS starting place, and its dysfunction, mainly in the normal anticoagulant, antioxidant and anti-cell adhesion was decreased. Oxidized low density lipoprotein (ox LDL) is caused by endothelial cell damage induced endothelial cell pro-inflammatory cytokines and the expression of the main pro-inflammatory molecules, and its oxidative modification process may occur in the cell lysosomes (2). In view of ox LDL plays an important role in the formation of AS to remove ox LDL may be the treatment of AS has future strategy (3). These high expression of proinflammatory media, including its main role is to induce such as monocyte