Bleeding sap bitter gourd powder spray hypoglycemic and acute toxicity studies.docVIP

 PAGE \* MERGEFORMAT 14 Bleeding sap bitter gourd powder spray hypoglycemic and acute toxicity studies [Abstract] Objective To study the bitter exudate hypoglycemic effect of dry powder spray and acute toxicity. Methods of streptozotocin (STZ)-induced diabetic mice model was xylem sap bitter spray powder on fasting blood glucose levels in diabetic mice , lipid levels and liver glycogen content, and by acute toxicity test to determine their LD50. Results bitter powder spray exudate in diabetic mice significantly reduced fasting blood glucose and blood lipid levels, and increased liver glycogen content in diabetic mice ; acute toxicity test results showed that the bleeding sap bitter spray dry powder oral LD50 in the 11 400 ~ 12 300 mg / kg between the toxicological reference to the acute toxicity of food grade standard, bitter gourd powder bleeding sap is actually non-toxic spray . Conclusion bitter exudate powder spray can be used as auxiliary hypoglycemic diabetic food. [Keywords:] spray dry bitter exudate; hypoglycemic; acute toxicity Diabetes is a common metabolic diseases, and its incidence increased year by year, the diabetes prevention and treatment of growing concern. Gourd used along with food and medicine, is a famous folk herbal medicine in China has five hundred years of application history [1 ]. lt;lt;Compendium of Materia Medicagt;gt; said: bitter “to the evil heat, solution Laofa, pure heart and eyesight” [2]. In recent years, many of pharmacology and experimental studies have shown that bitter gourd extract has hypoglycemic activity [3 ~ 5] . xylem sap of plants was cut off plant stems in the root xylem sap flow under pressure of the sap in vitro [6]. Modern research shows that plants contain a large number of xylem sap mineral elements, plant hormones, sugars, proteins, phenolic and other active substances [7]. charantia bleeding sap is harvested in the bitter end, to a certain height off the main stem after the incision in the effluent