Brain atrophy in Alzheimer disease and blood-brain barrier in the correlation.docVIP

 PAGE \* MERGEFORMAT 11 Brain atrophy in Alzheimer disease and blood-brain barrier in the correlation Study: King Han Jian-Chun Yu Yana on offer [Keywords:] brain atrophy, blood-brain barrier, Alzheimer’s disease Alzheimer’s disease (AD is an age-related neurodegenerative diseases, for disorders of recent memory as the main clinical symptoms, etiology unknown. The pathology showed diffuse brain atrophy, blood-brain barrier (blood brain barrier , BBB has defects. at home and abroad have reported little relationship between brain atrophy and the BBB, what is brain atrophy increased BBB permeability, the blood circulation of pathogens and potentially harmful process of small molecules through the BBB (1) or increased BBB permeability induced brain inflammation, eventually leading to brain atrophy is unclear. This article explores the relationship between them. 1 brain atrophy in AD’s performance AD pathology showed diffuse brain atrophy, pathology can be found in the basal ganglia neurons in the cortex and extensive depigmentation, no significant residual synaptic nerve cells, astrocytes proliferation, presence of senile plaques, nerve degeneration and nerve-free particles neurofibrillary tangles and other (2,3). With normal aging, the brain’s nerve cells continues to decline. hippocampal neurons can be reduced by 10% to 60%, cortical neurons in various parts of the temporal lobe to the upper part of the absence of most of 55% (4). Many patients with early Alzheimer’s symptoms are not obvious, because the brain can delay some age-related compensatory mechanism for some clinical manifestations, such as nerve cell plasticity, including those without residual disease compensatory extension of nerve cells and the number of dendritic increased, this can delay the reduction and degeneration of nerve cells. In AD there is also the phenomenon of plastic dendritic tree, this may be an attempt to biological protection (4). Neuropsychological studies hav