Brain heart tablet on cerebral ischemia protective mechanism.docVIP

 PAGE \* MERGEFORMAT 11 Brain heart tablet on cerebral ischemia protective mechanism Of: Li Hui, Su Yunming, Meng Yan, Li Wan, Zhang Society [Abstract] Objective To observe brain heart tablet on cerebral ischemia-reperfusion injury, and further explore its mechanism. Methods middle cerebral artery intraluminal model of incomplete cerebral ischemia, brain heart health observation films before and after administration of the middle cerebral artery occlusion (MCAO) rats with neurological deficit behavior changes caused by flow cytometry on brain heart Tablet MCAO rat model of acute brain injury in apoptosis, detected by immunohistochemistry Brain heart tablet 24,48,72 h after cerebral ischemia brain COX 2 protein expression. Results After cerebral ischemia reperfusion injury 24,48,72 h brain COX 2 positive cells in the average gray value and the rate of neuronal apoptosis in the model group compared with the sham group, the difference was significant (P lt;0.01, heart health administration head high, medium and low dose group compared with the Ginkgo, the difference was statistically significant ( P lt;0.01 or P lt;0.05, heart health administration head high, medium and low dose group compared with the nimodipine group, the difference was significant (P lt;0.01 or P lt;0.05. Conclusions Cerebral ischemic heart tablet on has a protective effect, and follow a time dependent and dose-effect relationship, which may reduce the ischemic brain tissue and neuronal apoptosis, inhibition of COX 2 protein expression. [Keywords:] brain heart tablet, cerebral ischemia, reperfusion injury, apoptosis, COX 2 Cerebral vascular disease of the nervous system common disease, is the cause of death of the three diseases. Ischemic stroke is caused by a variety of reasons a clinical pathologic state, their brain tissue damage is to produce clinical signs pathology. In this disease prevention, treatment and rehabilitation, traditional Chinese medicine has a more significant ef