Children with moderate to severe asthma Interleukin -17 and the inflammatory response of neutrophils between.docVIP

 PAGE \* MERGEFORMAT 14 Children with moderate to severe asthma Interleukin -17 and the inflammatory response of neutrophils between Study: Blue Dan, Jing Tan Weiping Wu Baojing wheat Xiandi Fan Lingling Li Wenyi [Abstract] [Objective] Interleukin -17 (IL-17) in moderate to severe child asthma, airway neutrophil inflammation effect. [Method] in severe persistent asthma in children in 45 cases, of which degree of continuous group (20 cases) and severe persistent group (25 cases); to 20 cases of healthy children as control group. by enzyme-linked immunosorbent assay (ELISA) were detected in peripheral blood mononuclear cells (PBMC) and in CD3 CD28 monoclonal antibody stimulated the secretion of IL-17 level, testing the number of neutrophils in induced sputum; joint treatment of these patients were followed up 3 months to achieve clinical remission of asthma cases included 20 cases of remission, review the IL- 17 levels. Comparison between the different conditions the expression level of IL-17, IL-17 to understand the clinical disease and asthma in children, the relationship between airway inflammation. [Results] asthma IL-17 expression in PBMC was significantly higher than the control group ( 2 685 + - 1 081) pg / mL, including asthma group (5 355 + - 813) pg / mL was significantly higher than that of asthma remission (4 504 + - 687) pg / mL (P all lt;0.05); severe persistent group of children with PBMC expression of IL-17 levels (5 830 + - 807) pg / mL was significantly higher than moderate persistent group (4 962 + - 751) pg / mL (P lt;0.05); acute exacerbation of asthma in children with IL- 17 levels (5 355 + - 813) pg / mL and the proportion of neutrophils in induced sputum (Xmin = 0, Xmax = 98.8, M = 44.73)%, the proportion of blood neutrophils (51.72 + - 13.43)%, a positive correlation (r = 0.820,0.736, P lt;0.001). [Conclusion] moderate to severe asthma, peripheral blood mononuclear cells in the expression of IL-17 levels and clinical conditions with