Chinese medicine on intracellular calcium ion channels in Analysis and Prospects.docVIP

 PAGE \* MERGEFORMAT 15 Chinese medicine on intracellular calcium ion channels in Analysis and Prospects [Keywords:] myocardial cells, calcium ion channel, patch clamp technique, Chinese medicine, review Myocardial cells have two important characteristics: First, internal and external environment in the cell there is a huge difference between the ion concentration, and second, through specific short opening and closing of ion channels, membrane depolarization can cause a series of effects, including myocardial cell contraction and relaxation, including calcium channel plays a very important role. Found so far, the most important myocardial cells have both L-and T-type calcium channels, both belong to the same voltage-dependent calcium channels. L-type calcium channels located in, including all the ventricular myocardial cells, including, action potential plateau of its formation, the increase in intracellular calcium and plays an important role in muscle contraction, the channel is about -60 ~ -40 mV to be activated. T-type calcium channels are mainly located in the conduction and pacemaker cells, it is generally believed that diastolic depolarization and play a role in cardiac pacemaker activity, the channel is about -60 ~ -50 mV to be activated. Drugs acting on calcium channels are two major categories: the first category of calcium channel agonist, the current tools do more drugs, the second is the calcium channel blocker, is the clinical application of a broad class medicine. Calcium channel blockers on the main pharmacological effects of the cardiovascular system as follows: ① the frequency of heart negative, negative conduction, negative incentives, primarily for the treatment of arrhythmia, ② significantly on the coronary vasodilation, mainly for the treatment of angina pectoris. Calcium channel blockers have given such an important pharmacological action, the 20th century, 80’s, the original Chinese Medicine Research Institute Professor Che