Chinese medicine treatment of the mechanism of ulcerative colitis.docVIP

 PAGE \* MERGEFORMAT 15 Chinese medicine treatment of the mechanism of ulcerative colitis [Keywords:] ulcerative colitis, mechanism, Chinese medicine, review Ulcerative colitis (Ulcerative colitis, UC) is difficult due to cure, the recurrence rate was higher and there is a certain relationship with colon cancer, has been the World Health Organization as one of modern medical treatment is difficult, the general attention by the medical profession. In recent years, Chinese medicine treatment of the disease has made some progress, its efficacy mechanism has a lot of research, are summarized below. 1 Free Radical Damage The results show that, UC and oxygen free radicals (OFR) injury and immune dysfunction are closely related, low capacity of intestinal clearance OFR for the OFR accumulation of intestinal mucosa is one important mechanism of injury. Metabolites of lipid peroxidation MDA aldehyde (MDA) is triggered OFR unsaturated fatty acids on the cell membrane occurred the products of lipid peroxidation, and its content reflects the degree of tissue peroxidation. Jishi et al [1] found that peace can significantly enhance intestinal immunization UC Large Rat superoxide dismutase (SOD) levels, reduce colon tissue damage. Young et al [2] in the trinitrobenzene sulfonic acid (TNBS) method based on the rat model of UC to continue to build the equivalent of the stomach with active UC intestine damp-heat model, the role of casual observation of Stagnation. The results show that the bulk thermal stasis group and sulfasalazine (SASP) in serum and intestinal tissue SOD activity increased, damage index, MDA content and interleukin 6 (IL- 6) levels. 2 anti-inflammatory and immune UC pathogenesis of immunological mechanisms to tissue injury caused abnormal immune theory of the most talked about continuing to enlarge. The disease may occur by the sending and the persistence of antigenic stimulation factors to stimulate intestinal mucosal immune cells (includin