Chinese medicine on intracellular calcium ion channels in Research and Prospect.docVIP

 PAGE \* MERGEFORMAT 15 Chinese medicine on intracellular calcium ion channels in Research and Prospect [Keywords:] myocardial cells, calcium ion channel, patch clamp technique, Chinese medicine, review Myocardial cells have two important characteristics: First, internal and external environment in the cell there is a huge difference between the ion concentration, and second, through specific short opening and closing of ion channels, membrane depolarization can cause a series of effects, including myocardial cell contraction and relaxation, including calcium channel plays a very important role. now found that most myocardial cells are two kinds of L-and T-type calcium channels, both belong to the same voltage-dependent calcium channels. L type calcium channel distribution in all, including ventricular myocytes, including in its formation of the action potential plateau, the increase in intracellular calcium and plays an important role in muscle contraction, the channel is about -60 ~ -40 mV is activated. T-type calcium channels are mainly located in the conduction and pacemaker cell, it is generally believed that diastolic depolarization and play a role in cardiac pacemaker activity, the channel is about -60 ~ -50 mV to be activated. Drugs acting on calcium channels are two major categories: the first category of calcium channel agonist, the current tools do more drugs, the second is the calcium channel blocker, is the clinical application of a broad class medicine. Calcium channel blockers on the cardiovascular system of the main pharmacological effects as follows: ① the frequency of the heart are negative, negative conduction, negative incentives, primarily for the treatment of arrhythmia, ② significantly on the coronary vasodilation, mainly used in the treatment of angina pectoris. In view of such an important calcium channel blockers have the pharmacological effects of 80 years of the 20th century, the original Chinese Medicine Research Institute