Chronic obstructive pulmonary disease airway inflammation and its treatment prospects.docVIP

 PAGE \* MERGEFORMAT 19 Chronic obstructive pulmonary disease airway inflammation and its treatment prospects [Keywords:] chronic obstructive pulmonary disease; airway inflammation; treatment Chronic obstructive pulmonary disease (chronic obstructive pulmonary disease, COPD is a chronic disease worldwide, is the fastest growing developing countries, the prevalence of one of the diseases and the incidence of elderly population is very high. Chronic airway inflammation especially the small airways of chronic inflammation is the main pathological features, but the current nature of airway inflammation in COPD is not clear, the treatment can not completely prevent disease progression, this article on elderly COPD airway inflammation progress in research and treatment are reviewed. 1 COPD airway inflammation and older Smoking is known to cause COPD, the most important factors in old age, induced airway and lung parenchyma surrounding the inflammatory response. Have found that small airway wall of smokers increased infiltration of inflammatory cells, COPD patients with small airway wall infiltration of lymphocytes accounted for 15% of the total inflammatory cells, than non-smokers with airflow obstruction was significantly increased (1). stable COPD in the elderly often have bacterial colonization of lower respiratory tract, is also an important stimulus to airway inflammation, in turn frequently causes airway inflammation deteriorate. elderly COPD pathology characterized by neutrophils, macrophages, CD8 + lymphocytes increased mainly around the large airways, small airways, lung parenchyma and pulmonary artery in various parts of (2.) airway inflammation is characterized by airway wall lymphocytes play an important role, within the lumen of neutrophils and alveolar macrophages dominated, eosinophils in airway inflammation remains to be further observed changes. The pathophysiology of various inflammatory mediators and cytokines involved, more research