Chronic obstructive pulmonary disease sTREM1 and Its Significance Determination.docVIP

 PAGE \* MERGEFORMAT 7 Chronic obstructive pulmonary disease sTREM1 and Its Significance Determination [Abstract] Objective To investigate the chronic obstructive pulmonary disease (COPD) in peripheral blood and induced sputum in patients with myeloid cells, soluble triggering receptor expressed on  1 (sTREM  1) the concentration and its relationship with the relationship between the severity of the disease. Methods In 12 patients with COPD with acute exacerbation (AECOPD) in patients before treatment, treatment for 2 weeks with stable peripheral blood and sputum in sTREM  1 concentration and white blood cell count (WBC), and 12 healthy human peripheral blood sTREM  1 concentration. Analysis of peripheral blood and sputum of COPD in sTREM  1 concentration and forced expiratory volume in 1 second, accounting for the percentage of predicted value (FEV1% predicted value) relationship. Results COPD before treatment group and treatment group 2 weeks in the sputum sTREM  1 concentrations were significantly higher than those with stable group (P amp;lt;0.05). Before treatment group, 2 weeks of treatment group and the group with stable sTREM  1 in peripheral blood compared with the control group there was no significant difference (Pamp;gt; 0.05). COPD sputum pre-treatment group in the sTREM  1 concentration and the corresponding values of FEV1% expected a negative correlation, the impact of FEV1% in descending order of concentration of sputum sTREM  1 and gender. Conclusion sTREM  1 in the concentration of sputum can reflect the extent of airway inflammation in COPD and as a reference indicator to determine the prognosis of lung function, peripheral blood sTREM  1 concentrations do not accurately reflect the extent of severe airway inflammation. [Keywords:] Chronic obstructive pulmonary disease; airway inflammation; myeloid cells, soluble triggering receptor expressed on  1; white blood cell count; pulmonary function ABSTRACT: Objective To i