Chlorine phosphonate bone metastases in breast cancer prevention and control Application.docVIP

 PAGE \* MERGEFORMAT 14 Chlorine phosphonate bone metastases in breast cancer prevention and control Application Of: Du Hongxia Zhang Zhan Rui Fang Li Ping Mi Man [Keywords:] bisphosphonate; chlorine bisphosphonates; breast cancer; bone metastasis Advanced breast cancer bone is the most common sites of metastases, osteolytic tumor cells can cause structural damage, leading to partial dysfunction, pathological fractures and hypercalcemia, accompanied by severe pain, which seriously affect the quality of life of patients. So metastatic bone pain is the main treatment for cancer patients facing the problem (1). the current major clinical use of bisphosphonates (zoledronic acid) Drug treatment of malignant tumors caused by metastatic bone pain and hypercalcemia, in which the clinical application of CPA Salt has more than twenty years, mainly in the treatment of osteolytic destruction based malignancies such as breast cancer, prostate cancer patients with metastasis achieved better effect (2), and thus cause for concern. 1 CPA structure and mechanism of salt 1.1 The chemical structure of CPA and classification of salt chlorine bisphosphonates are bisphosphonates. Bisphosphonates similar basic structure, the basic structure of the activity of PCP, the carbon atom with R1 and R2 2 substituents R1 which mainly involved two-substrate binding phosphate and bone mineralization, R2 is determined by its biological activity. the role of various bisphosphonates on the strength of the carbon atoms on the type of side chain. According to the chemical structure and mechanism of action may be bisphosphate salt into two categories, one is nitrogen-containing bisphosphonates, used with alendronate (alendronate sodium), ibandronate (sodium ibandronate), pamidronate (pamidronate disodium) and azole zoledronic acid (zoledronic acid), etc.; another non-nitrogen-containing bisphosphonates, drugs commonly used chlorine Qu acid disodium (clodronate disodium) and for acid b