Chrysophanol on cerebral ischemia-reperfusion in mice explore the function of.docVIP

 PAGE \* MERGEFORMAT 8 Chrysophanol on cerebral ischemia-reperfusion in mice explore the function of Author: Wang Shu-fang XUE Gui-Ping Zhang Zhang Salvia [Abstract] Objective To observe the chrysophanol on cerebral ischemia-reperfusion in mice to explore cognitive function. Methods temporary bilateral common carotid artery occlusion was prepared by cerebral ischemia-reperfusion injury in mice models to explore experiments, observations chrysophanol 10,1,0.1 mg * kg-1 ip on cerebral ischemia-reperfusion of small the improvement of cognitive function of mice to explore the role of, and each dose group in whole blood glutathione peroxidase (GSH-Px) activity and plasma superoxide dismutase (SOD) activity were measured. The results can be significantly reduced chrysophanol cerebral ischemia-reperfusion in mice to reach darkroom time to reach the end of time, to the Tat-ming room time to increase the number of high-end climbing, so that mice in the darkroom and in the next room residence time close; and improve the whole blood the GSH-Px activity and plasma SOD activity. Conclusion chrysophanol on cerebral ischemia-reperfusion in mice to explore cognitive dysfunction due to a marked improvement over the role, its role is to enhance the antioxidant enzyme mechanism may GSH-Px and SOD activity. [Keywords:] chrysophanol cerebral ischemia-reperfusion glutathione peroxidase superoxide dismutase Abstract: ObjectiveTo observe the effects of chrysophanol on cognitive and exploratory functions in mice with cerebral ischemia reperfusion.MethodsCerebral ischemia reperfusion injury was produced on conscious mice by temporarily obstructing bilateral common carolid arteries. The improvement effects of chrysophanol (10,1,0.1 mg * kg-1, ip) on cognitive and exploratory functions in mice with cerebral ischemia reperfusion was observed using exploratory movement test and the glutathione peroxidase (GSH-Px) activities in blood and the superoxide dismutase (SOD) activities in pla