Chorionic villi in early spontaneous abortion of nuclear transcription factorkappa B Expression.docVIP

 PAGE \* MERGEFORMAT 15 Chorionic villi in early spontaneous abortion of nuclear transcription factorkappa B Expression [Abstract] Objective To investigate the nuclear transcription factor B (NF B) in chorionic villi expression and activation and early spontaneous abortion. Methods Using immunohistochemical detection of early spontaneous abortion patients and healthy women over the same period of pregnancy in chorionic villi in NF B The expression of p65 by confocal microscopy (CLSM) detection NF B p65 and cytoplasmic to nuclear area ratio (FN / FC) in order to observe its activation. the result of early spontaneous abortion syncytiotrophoblast expression of NF B below normal early pregnancy women, the difference was statistically significant (P lt;0.001), spontaneous abortion in early mesenchymal cells the expression of NF B FN / FC (0.7602) was significantly higher than normal early pregnant women (0.6977) (t = 3.511, P lt;0.001). Conclusion NF B in early spontaneous abortion villi syncytiotrophoblast cells and low expression in mesenchymal cells may be associated with excessive activation of the occurrence of early spontaneous abortion. [Keywords:] early spontaneous abortion of nuclear transcription factor B immunohistochemical confocal laser scanning microscope trophoblast ABSTRACT: Objective To examine the cellular distribution and expression, activation of nuclear factor B (NF B) in the tissuses of chorion of early spontaneous abortion, and explore the relationship between early spontaneous abortion and NF B. Methods The NF B expression on the chorionic villi was analyzed by SP immunohistochemistry. The nucleoplasmic ratio of NF B was detected by laser scanning confocal microscope. Results The expression intensity of NF B in the syncytiotrophoblasts was significantly weaker in women with early spontaneous abortion than in the normal early pregnancy (P lt;0.001 ). Significant difference existed in the nucleoplasmic ratio of NF B expression in stro