Class chymase in liver tissue concentration of alcoholic liver fibrosis in the meaning of.docVIP

 PAGE \* MERGEFORMAT 8 Class chymase in liver tissue concentration of alcoholic liver fibrosis in the meaning of Study: Real Cuihe Song Choi Young-Ji Yin Ming [Abstract] Objective: To evaluate the liver tissue of Chymase (Class of chymase concentration in the alcoholic liver fibrosis. Methods: Using enzyme-linked immunosorbent assay (ELISA detected 48 cases of alcoholic liver fibrosis in patients with liver Chymase concentration and 28 cases of acute hepatitis to do comparison, using immunohistochemical staining labeled monoclonal antibody Chymase distribution of mast cells. Results: The patients with alcoholic liver fibrosis in liver tissue Chymase concentration of 17.53 + -4.39ng/mg, significantly higher in acute hepatitis (2.81 + -1.03ng/mg, P lt;0.01; immunohistochemical staining, Chymase labeled mast cells were mainly distributed in the fibrosis of liver cells around the strong and central venous around parts of its distribution is consistent with the fibrosis , and Chymase in liver tissue in patients with high concentrations in liver tissue distribution of Chymase marked increase in mast cells. Conclusion: Chymase levels in liver tissue may be closely related with alcoholic liver fibrosis. [Keywords:] Chymase, alcoholic liver fibrosis, mast cells, fibrosis, angiotensin Chymase is present in secretory granules in mast cells of a protease, which in non-angiotensin converting enzyme (ACE under way, so that angiotensin Ⅰ (Ang Ⅰ converted to angiotensin Ⅱ (Ang Ⅱ). In recent years, mast cells the relationship between fibroblast attention, mast cells secrete Chymase is the predecessor of fibroblasts, which in the interstitial connective tissue differentiation. Research report, Chymase and cardiac, renal interstitial fibrosis and other closely related [1]. previous studies that mast cells are closely related with liver fibrosis in chronic liver disease. alcoholic liver fibrosis is the primary metabolite of alcohol and acetaldehyde under the action