CLT compound particles on rat liver toxicity study.docVIP

 PAGE \* MERGEFORMAT 11 CLT compound particles on rat liver toxicity study [Abstract] Objective To study the lipid particles of compound-ching on rat liver toxicity. Methods Rats were fed a row to give clear resin compound particles Pharmacognosy 52,26, and 13 g / kg for 8 weeks at the same time as control group. After 12 h fasting water together chloral anesthesia animals, the liver weighed and calculated liver coefficient, the light microscope do histopathological examination and determination of serum AST, ALT, ALP and liver tissue SOD and MDA. Results of compound CLT particles 52 g / kg group of rats, liver weight, liver factor, the amount of liver tissue MDA were significantly higher, but the SOD activity and no significant difference between the control group, 26 g / kg group liver coefficient and liver tissue MDA higher, 13 g / kg group and the control all the indicators there was no significant difference between groups. Histological examination of each group were no obvious pathological changes in liver tissue. Conclusions Long-term given compound CLT particles 52,26 g / kg, have a certain toxicity to the liver, but there is no organic cause liver damage, 13 g / kg is the role of non-toxic doses. [Keywords:] rat; liver toxicity; superoxide dismutase; malondialdehyde Abstract: ObjectiveTo study the side-effects of Fufang Qingzhi (FFQZ) granules in rat liver. MethodsRats were intragastrically treated with Fufang Qingzhi granules (52, 26, 13g/kg) once a day for 8 weeks and the control group with water.Rats were anesthesia by chloral hydrate after fasting for 12 hours. Liver weight was measured, and liver coefficient was calculated. Histopathological examination for the liver was also performed with light microscopt.Activities of aspartate amino transferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) in serum and activity of superoxide dismutase (SOD) and concentration of malondialdehyde (MDA) in liver tissue were determined.Result