Codonopsis lanceolata extract on cerebral embolism in rats lysophosphatidic acid and phosphatidic acid levels.docVIP

 PAGE \* MERGEFORMAT 10 Codonopsis lanceolata extract on cerebral embolism in rats lysophosphatidic acid and phosphatidic acid levels Of: Lv Lixun Gang Han Dong Hai Zhong Wang Chengjiang on the original [Abstract] Objective To study the ethanol extract of Codonopsis lanceolata on cerebral embolization plasma lysophosphatidic acid (LPA and phosphatidic acid (PA levels. Methods carotid artery catheter directly into the rat cerebral embolism thrombin model. SD 40 rats were randomly divided into normal control group, model group, sham operation group, Codonopsis lanceolata extract low and medium dose groups. In addition to the normal control group, the other 4 groups established model of cerebral embolism . Codonopsis lanceolata extract group by oral administration in advance 14 d of ethanol extract of Codonopsis lanceolata, Codonopsis lanceolata observed ethanol extract in rats after cerebral embolism levels of LPA and PA. The results compared with the control group rats, the plasma hemolytic LPA and PA levels (P lt;0.05, Prophylactic Codonopsis lanceolata ethanol extract significantly decreased plasma levels of LPA and PA (P lt;0.05. Conclusions of ethanol extract of Codonopsis lanceolata may reduce cerebral embolism in rat plasma levels of LPA and PA. [Keywords:] lanceolata, lysophosphatidic acid, phosphatidic acid, cerebral embolism Codonopsis lanceolata (Codonopsis lanceolata) Campanulaceae Codonopsis is a perennial herb distributed in Northeast China, South China, Southwest and other places (1). Lanceolata vitamins, saponins, polysaccharides, flavonoids, Qi Pier acid and volatile oil, can inhibit tumor growth, fatigue, blood fat, such as antioxidant and free radical scavenging effect (2 to 4), human platelets have anticoagulation effects (5), but rare reports of anti-thrombotic . phospholipid metabolism intermediates lysophosphatidic acid (lysophosphatidic acid, LPA) and phosphatidic acid (phosphatidic acid, PA), in the (heart) the occurrence of s